cbd hydrosoluble is a potent inhibitor of -amyloid plaque accumulation, inhibiting neuroinflammation and protecting against neuronal death. It is also an allosteric receptor modulator, enhancing or inhibiting how a receptor transmits a signal by changing the shape of the receptor (CB1 vs. CB2). CBD also reduces anxiety by enhancing the binding affinity of GABA-A receptors to their principal endogenous agonist, gamma-aminobutryic acid, which decreases nerve activity and promotes relaxation.
CBD has been shown to interact with a variety of molecular targets, including the 5-HT1A serotonin receptor and cannabinoid-related receptors GPR55 and transient receptor potential vanilloid 1 (TRPV1). It is also known to exert antitumor effects, as well as antidepressant and anxiolytic properties. CBD has also been shown to affect cardiovascular parameters such as heart rate and blood pressure, but these changes are inconsistent among studies.
The Science Behind CBD Hydrosoluble Technology
In this article, the authors developed nanostructured lipid carriers for nasal administration that were loaded with CBD. The nanoparticles were prepared by the hot microemulsion technique using stearic acid as solid lipid, oleic acid as liquid lipid and cetylpyridinium chloride as surfactant for mucoadhesive and stabilizing properties. The particles had a mean size of 156 + 102 nm and a PDI of 0.17 + 0.05, and the release kinetics were evaluated in simulated intestinal media.
The lecithin-stabilized and HPMCAS-stabilised nanoparticles exhibited immediate complete burst release, whereas the bulk crystalline CBD showed a limited dissolution over the 6 h in vitro period. Both formulations displayed rapid dissolution kinetics in simulated intestinal medium, which was six-fold higher than the bulk crystalline CBD.